Dragons kick-off a busy spell of Welsh derby fixtures at Cardiff Arms Park on Friday night as they take on Cardiff Blues (kick-off 7.35pm).
Ospreys are next up at Rodney Parade on December 30 before a New Year trip to Scarlets.
Wales international Wainwright, 21, acknowledges it is a crucial time for the region as they look to secure a Welsh derby victory and he believes the team spirit and togetherness is as strong as ever ahead of the opening derby clash.
“This is going to be a big period for us, especially after what has happened,” said Wainwright. “It is important for us to stay nice and tight as a group, if we do that then I don’t see why we can’t come away with some good results.
“There is a lot of potential here, you can see the squad that we have got on paper and it’s just about putting the performances in.
“As soon as we can find what makes us tick and find some good performances then we will be able to push on and compete with the best in the league.
“Against Clermont we fronted up really well and were really physical,” he added.
“We knew that they were going to be a tough outfit because they are one of the best teams in Europe let alone the Challenge Cup.
“We pulled together really well as a team and stuck tight as a unit, and that has put us in good stead for this week.
“Clermont were really physical and the Blues will be as well, so if we can be as physical as last week, finish off some chances and stay a bit tighter in defence then we will be alright.
“With what has happened we have stayed really tight as a group, everyone has pulled together and that was especially important going away in Europe.
“That showed on the pitch, we worked for each other and were physical. We just need to take that into this week and over the Christmas period to get some results.”
CLICK HERE to secure your tickets for the festive fixture against the Ospreys at Rodney Parade on 30 December with Early Bird tickets on sale until Christmas Eve.