Scrum-half Keira Bevan and wing Jaz Joyce are involved for the first time this year. Bevan returns from an ankle injury suffered on international duty during the autumn, whilst Joyce has been involved in sevens preparations for next month’s Commonwealth Games in Australia.
Elsewhere, Jess Kavanagh-Williams is the only player remaining from the back three which turned out against Ireland in Dublin a fortnight ago, with Hannah Jones starting at fullback and Joyce on the right wing.
With an unchanged pack, the only other change in the team sees Robyn Wilkins brought in at
“We’ve shown enough glimpses of our potential, both in victory and defeat, to give us a lot of encouragement,” said head coach Rowland Phillips. “We’ve got a great platform now to show the Welsh public what women’s rugby is all about, and in particular what Wales Women are about as a team. I hope we can do that on Sunday.”
On playing at Wales’ national stadium, Phillips said: "It's a huge opportunity for us, and it's great that the WRU has given us this chance to play in the best stadium in the world. There's an incentive there in the venue alone, but our focus needs to be Italy and getting our game right."
Should she be called into action from the bench, former netball and hockey player Alecs Donovan could make her debut at Principality Stadium, following a Player of the Match performance in the uncapped match against the Armed Forces last November.
Wales Women team to face Italy:
15 Hannah Jones (Scarlets) 14 Jaz Joyce (Scarlets) 13 Kerin Lake (Ospreys) 12 Robyn Wilkins (Ospreys) 11 Jess Kavanagh-Williams (RGC) 10 Elinor Snowsill (Dragons) 9 Keira Bevan (Ospreys) 1 Caryl Thomas (Scarlets) 2 Carys Philips (c) (Ospreys) 3 Amy Evans (Ospreys) 4 Siwan Lillicrap (Ospreys) 5 Mel Clay (Ospreys) 6 Alisha Butchers (Scarlets) 7 Beth Lewis (Scarlets) 8 Sioned Harries (Scarlets)
Replacements: 16 Kelsey Jones (Ospreys) 17 Gwenllian Pyrs (RGC) 18 Meg York (Dragons) 19 Natalia John (Ospreys) 20 Nia Elen Davies (Scarlets) 21 Jade Knight (Scarlets) 22 Alecs Donovan* (Ospreys) 23 Lisa Neumann (Scarlets)